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Discovery of epitopes governing MMP-12 specificity for fibrillar substrates : BINDSIght, a method for determining specific sites of substrate surface interactions
(University of Missouri--Columbia, 2008)
and collagen V substrate mimics without compromising activity upon a small broad range MMP substrate. Since the entire family of MMPs differ very little in sequence of the active site, it makes sense that exosites contribute to MMP-12 activity....